Tạp chí Y học Quân sự

EVALUATION OF TREATMENT RESULTS IN 10 PATIENTS WITH SOFT TISSUE DEFECTS IN THE WRIST-HAND REGION USING RADIAL ARTERY PERFORATOR FLAPS

Vu Quoc Khanh — 2024-02-28

Purpose: Evaluate the treatment results of soft-tissue defects in the wrist-hand region by radial artery perforator flaps.

Subjects and methods: A prospective, non-controlled study and cross-sectional description of 10 patients with soft-tissue defects in the wrist-hand region due to burns, indicated for reconstructive treatment using radial artery perforator flaps at the Center for Plastic and Aesthetic Surgery, Le Huu Trac National Burn Hospital, from January to September, 2021.

Results: Patients aged between 17 and 69, mean age of 37.3 ± 14.5 years; ratio of male patients to female patients was 4/1. Regarding the location of injuries: 9 patients had soft-tissue defects in the dorsum of the wrist-hand; 1 patient had a soft-tissue defect in the volar aspect of the wrist-hand. Regarding treatment results: 8 patients showed excellent treatment results, 2 patients had satisfactory results, and there were no cases of treatment failure.

EVALUATION OF SURGICAL OUTCOMES OF OSTEOPOROTIC VERTEBRAL COMPRESSION FRACTURE PATIENTS TREATED BY KYPHOPLASTY, AT MILITARY HOSPITAL 105

Nguyen Thanh Bac — 2024-02-28

Purpose: To evaluate the surgical outcomes of osteoporotic vertebral fracture patients treated by kyphoplasty at Military Hospital 105.

Subjects and Methods: A descriptive, retrospective study of 34 osteoporotic fractures patients who were treated by kyphoplasty at Military Hospital 105 from January 2021 to December 2021.

Results: Immediately post operation, 100% of patients had significant pain relief compared to preoperation (average VAS score after surgery 1.91 ± 1.22); 100% of patients had vertebral body height restored (with moderate level 36.4%, good level 39.4%); The kyphosis corrected spine has statistical significance compared to before treatment (with p < 0.05).

THE INITIAL TREATMENT RESULTS OF 6 PATIENTS WITH NON-SMALL CELL LUNG CANCER WITH EGFR AND ALK CONCURRENT MUTATIONS, AT THE CENTRAL LUNG HOSPITAL

Le Tu Linh — 2024-02-28

Purpose: Evaluate the initial treatment results of non-small cell lung cancer with EGFR and ALK concurrent mutations.

Subjects and methods: A prospective study, non-controlled description, and longitudinal follow-up of 6 patients with stage IIIB-IV non-small cell lung cancer, with EGFR and ALK concurrent mutations, at the National Lung Hospital, from January 2022 to July 2023.

Results: The average age of patients was 65.5 years, the male/female gender ratio was 5/1, and the proportion of patients who smoked was 83.3%. Patients were mainly admitted to the hospital due to symptoms of cough (100%), chest pain (50.0%), and dyspnea (33.3%); the majority of patients with stage IV cancer (83.3%); all patients had adenocarcinoma (100%). The average disease-free survival time was 11.36 months. The common unwanted effects were mainly skin rash (83.3%) and diarrhea (66.7%). Elevated liver enzymes and renal failure occurred in the group of patients using a combination of EGFR-TKIs and ALK-TKIs and were the reasons for discontinuation of ALK-TKIs.

EVALUATION OF THE THERAPEUTIC SUPPORT EFFECTS OF LIGHT THERAPY FOR PATIENTS WITH SEVERE ACNE VULGARIS

Nguyen Thi Dieu Thuy — 2024-02-28

Objective: To evaluate the treatment results of combined blue light (415 nm wavelength) and red light (633 nm wavelength) therapy for patients with severe acne vulgaris.

Subjects and methods: A pre-post comparative interventional study on 30 patients with severe acne vulgaris, examined and treated at the Central Dermatology Hospital from July 2022 to June, 2023.

Results: The female-to-male patient ratio was approximately 2.3/1. Patients aged 16-25 accounted for 70.8%, and 46.7% had family members with acne. Clinically, 100% of patients had facial lesions (with 97.8% of lesions in the cheek area). The number of inflammatory and non-inflammatory lesions gradually decreased from week four to week 12 of treatment. The differences between treatment weeks and pre-treatment were statistically significant, with p < 0.05. Good and very good treatment results increased for both genders after four, eight, and 12 weeks of the treatment, with statistically significant changes (p_1-2 < 0.05 and p_3-1 < 0.05). Dry lips remained a common unwanted effect at the end of treatment (60.0%).

Conclusions: Treatment of severe acne vulgaris with isotretinoin combined with blue light and red light had a good treatment effect after 12 weeks of treatment.

ASSESSMENT OF UNWANTED EFFECTS OF CONCURRENT CHEMORADIOTHERAPY FOR NASOPHARYNGEAL CARCINOMA, AT THE NATIONAL OTORHINOLARYNGOLOGY HOSPITAL OF VIETNAM, FROM 2019 TO 2023

Le Van Thanh — 2024-02-28

Purpose: Assessment of the unwanted effects of concurrent chemoradiotherapy for nasopharyngeal carcinoma.

Subjects and methods: A retrospective combined prospective study and description of 53 patients with stage II-IVA nasopharyngeal carcinoma, treated with concurrent chemoradiotherapy by the cisplatin regimen on days 1, 22 and 43 at the National Otorhinolaryngology Hospital of Vietnam from 2019 to 2023.

Results: The incidence of grade 3 toxicity on the hematopoietic and non-hematopoietic systems, and late complications occurred at a low rate. Specifically: toxicities of leukopenia and granulocytopenia at grade 3 were 17.0%, and 7.5% respectively; toxicity: dermatitis, mucositis, and, nausea at grade 3 were 3.8%, 18.9%, and 5.7%, respectively. Late complications of xerostoma and skin fibrosis at grade 3 were 18.9% and 1.9%, respectively.

EVALUATION OF EMOTIONAL DISTRESS IN A COHORT OF NEWLY DIAGNOSED CANCER PATIENTS: A STUDY OF 67 INDIVIDUAS

Dang Thi Huong — 2024-02-28

Purpose: To evaluate distress in newly diagnosed cancer patients.

Subjects and Methods: Cross-sectional prospective study of 67 newly diagnosed patients at the Department of Pain management and Palliative Care, 108 Military Central Hospital, from August to October 2023. The patient's level of distress was assessed by the Distress Thermometer - DT and the Problem List (PL) of NCCN February 2022, Vietnamese version.

Results: The average distress score among newly diagnosed cancer patients was 4.42 ± 2.237, with 3% reporting no distress, 44.8% experiencing mild distress, and 52.2% reporting moderate to severe distress (≥ 4 points). Common sources of distress among the participants included physical discomfort (94.0%), with 73.1% reporting sleep problems and 71.6% experiencing fatigue. Emotional challenges were prevalent as well (91.0%), with 49.3% reporting feelings of sadness and 47.8% experiencing anxiety. Additionally, concerns regarding self-care (53.7%) and financial worries (43.3%) were notable contributors to distress, accounting for 76.1% of the participants' concerns overall. The rate of moderate and severe distress in newly diagnosed cancer patients were statistically significantly related to age (more prevalent in patients under 60), gender (higher in females) education level (more in those with secondary school education or less), income (higher in those with below-average incomes), health insurance benefits (higher in patients with less comprehensive coverage).

STUDY ON THE ANTAGONISTIC ACTIVITY AGAINST TWO PATHOGENIC BACTERIA IN HUMANS OF STREPTOMYCES MIP_L26 ISOLATED FROM SOIL IN THE ROOT ZONE OF THE MAY CHANG TREE (LITSEA CUBEB)

Chu Thanh Binh — 2024-02-28

Purpose: Study on the antagonistic activity against two pathogenic bacteria in humans (Staphylococcus aureus and Streptococcus pneumoniae) of the Streptomyces MIP_L26 (Called MIP_L26), isolated from the soil in the root zone of the May Chang tree; to investigate the biological characteristics of MIP_L26

Subjects and methods: Experimental study, determine the antimicrobial activity against two pathogenic bacteria in humans (Staphylococcus aureus and Streptococcus pneumoniae), and some biological characteristics of MIP_L26.

Results: MIP_L26 was identified as having a strong antagonistic ability against the two bacteria causing Staphylococcus aureus and Streptococcus pneumoniae with an antibacterial ring diameter of 18 ± 5 mm and 13 ± 5 mm, respectively. Based on classification according to morphological, physiological, and biochemical characteristics, combined with the results of 16S rRNA gene sequencing, MIP_L26 was identified as Streptomyces gancidicus MIP_L26. The fermentation medium for the biosynthesis of antibacterial substances was ISP6 and the recovery time for antimicrobial substances was after 72 hours of fermentation.

CIRCULATING PROTEINS AS DIAGNOSTIC BIOMARKERS IN BREAST CANCER

Dinh Thi Thao — 2024-02-28

Purpose: Summary of tumor-produced circulating proteins as biomarkers in breast cancer (BC) detection.

Subjects and method: A meta-analysis of 50 researches on protein biomarkers in BC diagnosis.

Results: Many studies have shown that tumors continuously release components such as protein, RNA, and DNA into the bloodstream during apotosis. There are different protein markers, as tissue markers and serum markers involved assisting diagnosis, but none of them can independently establish the final diagnotic BC at an early stage. Therefore, scientific communities have been putting lots of effort to discover biomarkers for better identifying this malignant disease at earlier stages.

STUDY ON THE ACTUAL SITUATION OF DOMESTIC WATER IN 24 MILITARY UNITS IN THE NORTHERN REGION IN 2022

Tran Quoc Luat — 2024-02-28

Purpose: Study on the actual situation of domestic water in some military units in the Northern region in 2022.

Subjects and Methods: A cross-sectional descriptive study with analysis and evaluation of seven basic physical, chemical and microbiological indicators on 113 samples of domestic water collected at 24 military units stationed in the Northern Region from July to October, 2022.

Results: The water used for consumption and daily activities in the studied units accounted for 58.4% from drilled wells and dug wells and 35.4% from water supplied by factories, in which 61.1% of the water was untreated before use. The proportion of water sources that did not meet the standards according to QCVN 01:2018/BYT for pH indicator was 29/113 samples (25.7%), and for turbidity was 10/113 samples (8.8%). A comparison of nitrite and ammonia standards between treated and untreated water sources showed approximate equality. The difference in permanganate criteria between treated and untreated water sources and the proportion of samples meeting standards according to QCVN 01-1: 2018/BYT was statistically significant with p < 0.05.

ACUTE AND SUB-CHRONIC TOXICITY ASSESSMENT OF PYRIDOSTIGMINE BROMIDE 90 MG EXTENDED- ELEASE TABLETS IN EXPERIMENTAL ANIMALS

Do Phong Tue — 2024-02-28

Purpose: This study aimed to assess the acute and subchronic toxicity of Pyridostigmine bromide 90 mg extended-release tablets in experimental animals.

Subjects and methods: Pyridostigmine bromide 90 mg extended-release tablets were prepared complying in-house specifications. Acute oral toxicity (LD50) was determined in white mice using the Litchfield-Wilcoxon method. Subchronic toxicity was assessed in rabbits following OECD guidelines.

Results: The acute toxicity study revealed an LD50 of 17.9 mg/kg when Pyridostigmine bromide 90 mg extended-release tablets were orally administered to mice. In the subchronic toxicity assessment, rabbits were treated with Pyridostigmine bromide tablets for 28 days. Doses of 7.2 mg/kg/day and 21.6 mg/kg/day showed no significant alterations in hematological parameters (red blood cells, hemoglobin, hematocrit, mean corpuscular volume, white blood cells, platelets), blood biochemical parameters (AST, ALT, total protein, creatinine, urea), and did not cause damage to the histopathology of the liver, spleen, and kidneys in rabbits. However, the dose of 21.6 mg/kg/day resulted in a statistically significant difference in rabbit weight gain compared to those administered a dose of 7.2 mg/kg/day and those in the control group.

ANALGESIC EFFECT OF “DINH THONG PHONG” CAPSULES ON EXPERIMENTAL ANIMALS

Tran Thanh Tuan — 2024-02-28

Purpose: Evaluate the analgesic effect of “Dinh Thong Phong” capsules on experimental animals.

Subjects and Methods: “Dinh Thong Phong” capsules, meeting the standard criteria, were evaluated for analgesic effect on white mice. In particular, the central analgesic effect was assessed using the hot plate model, peripheral analgesic effect was assessed using the writhing pain model.

Results: In the hot plate model, “Dinh Thong Phong” capsules at a dosage of 860 mg/kg and 2,580 mg/kg significantly increased the reaction time to heat (p < 0.001) compared to the control group. The difference in reaction time to heat between the groups using “Dinh Thong Phong” capsules and the group using codeine phosphate at a dose of 20 mg/kg was not statistically significant (p > 0.05). In the writhing model, “Dinh Thong Phong” capsules at a dose of 860 mg/kg and 2,580 mg/kg significantly reduced the number of writhing episodes (p < 0.001) compared to the control group. The difference in the number of writhing episodes between the groups using “Dinh Thong Phong” capsules and the group using aspirin at a dose of 150 mg/kg was not statistically significant (p > 0.05).

EVALUATION OF ACUTE AND SEMI-CHRONIC TOXICITY OF THE REMEDY “BO PHE DINH SUYEN QY” ON EXPERIMENTAL ANIMALS

Nguyen Thanh Ha Tuan — 2024-02-28

Purpose: To evaluate the acute toxicity and semi-chronic toxicity of the remedy “Bo phe dinh suyen QY” on experimental animals.

Subjects and methods: The remedy “Bo phe dinh suyen QY” meeting basic standards was used to evaluate for acute toxicity in Swiss white mice, and for semi-chronic toxicity in Wistar white rats. Acute toxicity was assessed according to the Litchfield-Wilcoxon method. Sub-chronic toxicity was assessed according to the guidance of the Ministry of Health of Vietnam.

Results: The remedy “Bo phe dinh suyen QY” at a dose of 375 g/kg mouse body weight/24 hours did not cause acute toxicity or death of experimental mice. For 28 consecutive days, rats administered “Bo phe dinh suyen QY” at doses of 18.2 g/kg/day and 54.6 g/kg/day without affecting their general condition and hematological indices.

Conclusions: The remedy “Bo phe dinh suyen QY” was safe in the assessment of acute toxicity (on mice) and semi-chronic toxicity (on rats).

EVALUATION OF THE INITIAL RESULTS OF APPLYING INFORMATION TECHNOLOGY TO PREVENT CONTRAINDICATED DRUG INTERACTIONS IN PRESCRIPTIONS AT THE MILITARY HOSPITAL 7, MILITARY REGION 3

Nguyen Phuong Dong — 2024-02-28

Purpose: Building a list of contraindicated drug interactions and evaluating the initial results of applying information technology to prevent contraindicated drug interactions in prescriptions at the Military hospital 7.

Subjects and Methods: A retrospective, descriptive study evaluated 158,213 prescriptions before integrating the drug interaction warning utility and 18,222 prescriptions after integrating the drug interaction at the Military hospital 7.

Results: Successfully built and integrated 82 pairs of contraindicated drug interactions in Hospital information system (HIS) software, including 54 pairs with contraindicated drug interactions in combination and 28 pairs of contraindicated drug interactions in specific clinical contexts. In 158,213 prescriptions before integrating the drug interaction warning utility, 45 prescriptions with contraindicated drug interactions were identified (including nine prescriptions with contraindicated drug interactions in combination, with two pairs of drug interactions, and 36 prescriptions with contraindicated drug interactions in specific clinical contexts, with seven pairs of drug interactions). In 18,222 prescriptions after integrating real-time contraindicated drug interaction warnings on HIS software, no prescriptions with contraindicated drug interactions detected.

Conclusions: The initial application of information technology has improved a positive effect in preventing contraindicated drug interactions in prescriptions at Military hospital 7.