EVALUATION OF ACUTE AND SEMI-CHRONIC TOXICITY OF THE REMEDY “BO PHE DINH SUYEN QY” ON EXPERIMENTAL ANIMALS
DOI:
https://doi.org/10.59459/1859-1655/JMM.335Từ khóa:
Bo phe dinh suyen QY, acute toxicity, experimentTóm tắt
Purpose: To evaluate the acute toxicity and semi-chronic toxicity of the remedy “Bo phe dinh suyen QY” on experimental animals.
Subjects and methods: The remedy “Bo phe dinh suyen QY” meeting basic standards was used to evaluate for acute toxicity in Swiss white mice, and for semi-chronic toxicity in Wistar white rats. Acute toxicity was assessed according to the Litchfield-Wilcoxon method. Sub-chronic toxicity was assessed according to the guidance of the Ministry of Health of Vietnam.
Results: The remedy “Bo phe dinh suyen QY” at a dose of 375 g/kg mouse body weight/24 hours did not cause acute toxicity or death of experimental mice. For 28 consecutive days, rats administered “Bo phe dinh suyen QY” at doses of 18.2 g/kg/day and 54.6 g/kg/day without affecting their general condition and hematological indices.
Conclusions: The remedy “Bo phe dinh suyen QY” was safe in the assessment of acute toxicity (on mice) and semi-chronic toxicity (on rats).
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Chấp nhận đăng 23-02-2024
Ngày xuất bản 28-02-2024
