ASSESSMENT OF UNWANTED EFFECTS OF CONCURRENT CHEMORADIOTHERAPY FOR NASOPHARYNGEAL CARCINOMA, AT THE NATIONAL OTORHINOLARYNGOLOGY HOSPITAL OF VIETNAM, FROM 2019 TO 2023

Các tác giả

  • Le Van Thanh Ninh Binh provincial General Hospital
  • Nguyen Quang Trung Hanoi Medical University
  • Pham Dinh Khanh The National Otorhinolaryngology Hospital of Vietnam
  • Hoang Thi Thao The National Otorhinolaryngology Hospital of Vietnam

DOI:

https://doi.org/10.59459/1859-1655/JMM.330

Từ khóa:

Ung thư vòm mũi họng, tác dụng không mong muốn, tỷ lệ đáp ứng

Tóm tắt

Purpose: Assessment of the unwanted effects of concurrent chemoradiotherapy for nasopharyngeal carcinoma.

Subjects and methods: A retrospective combined prospective study and description of 53 patients with stage II-IVA nasopharyngeal carcinoma, treated with concurrent chemoradiotherapy by the cisplatin regimen on days 1, 22 and 43 at the National Otorhinolaryngology Hospital of Vietnam from 2019 to 2023.

Results: The incidence of grade 3 toxicity on the hematopoietic and non-hematopoietic systems, and late complications occurred at a low rate. Specifically: toxicities of leukopenia and granulocytopenia at grade 3 were 17.0%, and 7.5% respectively; toxicity: dermatitis, mucositis, and, nausea at grade 3 were 3.8%, 18.9%, and 5.7%, respectively. Late complications of xerostoma and skin fibrosis at grade 3 were 18.9% and 1.9%, respectively.

Tài liệu tham khảo

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with locoregionally advanced nasopharyngeal carcinoma: a Bayesian network meta-analysis of randomized controlled trials”, J. Cancer, 6, 883-892.

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Wei K.R, Y.Y.L, Yang Y.Y, et al (2010), “Epidemiological trends of nasopharyngeal carcinoma in China”, Asian Pac J Cancer Prev, 11 (1), 29-32.

Ngo Thanh Tung, N.V.T (2015), Oropharyngeal Cancer. Radiation Therapy for Head and Neck Cancers, Medical Publishing House, Hanoi, 95-127.

6.Đai L.C (2007), Study on Combined Chemoradiotherapy and Radiotherapy Alone for Stage III, IV Nasopharyngeal Cancer (Mo), Doctoral Thesis in Medicine, Hanoi University of Medicine.

Tao C.J, L.L, Zhou G.Q, et al (2014), “Comparison of long-term survival and toxicity of cisplatin delivered weekly versus every three weeks concurrently with intensity-modulated radiotherapy in nasopharyngeal carcinoma”, PLoS One, 9 (10), e110765.

Su Z, M.Y.P, Tang J, et al (2016), Long-term outcomes of concurrent chemoradiotherapy versus radiotherapy alone in stage II nasopharyngeal carcinoma treated with IMRT: a retrospective study. Tumour Biol, 37 (4), 4429-4438.

Kim T.H, K.Y.H, Lee M.A, et al (2008), “Treatment outcome of cisplatin-based concurrent chemoradiotherapy in the patients with locally advanced nasopharyngeal cancer”, Cancer Res Treat, 40 (2), 62-70.

DHQT (2012), Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma, Doctoral Thesis in Medicine, University of Medicine and Pharmacy, Ho Chi Minh City.

Tải xuống

Đã Xuất bản

28.02.2024

Cách trích dẫn

Le Van Thanh, Nguyen Quang Trung, Pham Dinh Khanh, & Hoang Thi Thao. (2024). ASSESSMENT OF UNWANTED EFFECTS OF CONCURRENT CHEMORADIOTHERAPY FOR NASOPHARYNGEAL CARCINOMA, AT THE NATIONAL OTORHINOLARYNGOLOGY HOSPITAL OF VIETNAM, FROM 2019 TO 2023. Tạp Chí Y học Quân sự, (368), 5. https://doi.org/10.59459/1859-1655/JMM.330

Số

Chuyên mục

NGHIÊN CỨU - TRAO ĐỔI
 Ngày nhận bài      09-10-2023
 Chấp nhận đăng  13-12-2023
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