EVALUATION OF ACUTE TOXICITY AND HYPOLIPIDEMIC EFFECT OF LOWLP-PT DRY EXTRACT IN WHITE MICE
DOI:
https://doi.org/10.59459/1859-1655/JMM.582Từ khóa:
Acute toxicity, hypolipidemic effect, Swiss albino mice, LOWLP-PT dry extractTóm tắt
Objectives: To evaluate the acute toxicity and hypolipidemic effects of the LOWLP-PT dry extract in white mice.
Subjects and methods: An experimental study was conducted on white mice to assess the acute toxicity of the LOWLP-PT dry extract according to OECD guidelines (2002, 2022) and the protocol by Do Trung Dam, using gradually increasing oral doses ranging from 500 to 5,000 mg/kg. The hypolipidemic effect was evaluated using a model of endogenous hyperlipidemia in mice induced by Poloxamer-407, at doses of 500 mg/kg and 1,000 mg/kg.
Results: To regarding acute toxicity: the LOWLP-PT dry extract was safe at the maximum tested dose of 5,000 mg/kg and no signs of toxicity or mortality were observed in the test animals; the LD₅₀ could not be determined. Regarding the hypolipidemic effect: compared to the disease control group, the LOWLP-PT dry extract significantly reduced total cholesterol (by 22.8% at 500 mg/kg and 30.8% at 1,000 mg/kg) and LDL-C levels (by 26.0% at 500 mg/kg and 27.5% at 1,000 mg/kg), with statistically significant differences (p < 0.05). Triglyceride levels showed a slight decrease, but the effect was not superior to that of the positive control group. HDL-C levels showed no significant differences among the experimental groups (p > 0.05).
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Ngày xuất bản 21-05-2025
